2015-present

Pre-print

A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres
Agasti, S.; Beltran, F.; Pye, E.; Kaltsoyannis, N.; Crisenza, G.E.M.; Procter, D.J.*
ChemRxiv. 2022 DOI: 10.26434/chemrxiv-2022-v93kv

2022

A general arene C–H functionalization strategy via electron donor-acceptor complex photoactivation
Dewanji, A.; van Dalsen, L.; Rossi-Aston, J.; Gasson, E.; Crisenza, G.E.M.; Procter, D.J.*
Nat. Chem. 2022, https://doi.org/10.1038/s41557-022-01092-y
ChemRxiv. 2021 DOI: 10.26434/chemrxiv-2021-xbn7k

• Highlighted in Nature Chemistry, News and Views –
'Radical Arenes', Bednar, T. N.; Nagib, D. A. Nat. Chem. 2023, 15, 3.
• Highlighted in RSC Chemistry World – www.chemistryworld.com/news/photochemistry-frees-arene-functionalisation-from-metals/4016777.article
• Highlighted in C2W International, Royal Netherlands Chemical Society – www.sciencelink.net/news/sulphonium-salt-radicalises-c-h-bonds/20951.article

A Vitamin B2-Photocatalysed Approach to Methionine Analogues
Knowles, O. J.; Johannissen, L. O.; Crisenza, G. E. M. Hay, S.; Leys, D.; Procter, D. J.*
Angew. Chem. Int. Ed. 2022, Accepted Article
https://doi.org/10.1002/anie.202212158
• Highlighted In Synfacts 2023; 19(01): 0075 DOI: 10.1055/s-0042-1751782

Pyrrolo[3,4-c]pyridine-1,2-dione: a new electron acceptor for electrochromic conjugated polymers
Vo, T. P.; Chua, M. H.; Ang, S. J.; Chin, K. L. O.; Soo, X. Y. D.; Png, Z. M.; Tam, T. L. D.; Zhu, Q.; Procter, D. J.;* Xu. J.*
Polym. Chem. 2022, Advanced Article
https://pubs.rsc.org/en/content/articlelanding/2022/py/d2py00863g

Diastereoselective Radical 1,4-Ester Migration: Radical Cyclizations
of Acyclic Esters with SmI2
Morrill, C.; Péter, Á.; Amalina, I.; Pye, E.; Crisenza, G. E. M.; Kaltsoyannis, N.; Procter, D. J.*
J. Am. Chem. Soc. 2022, 144, 13946
https://pubs.acs.org/doi/10.1021/jacs.2c05972

Asymmetric Total Synthesis of (–)-Phaeocaulisin A
Peter, Á.; Crisenza, G. E. M.; Procter, D. J.*
J. Am. Chem. Soc. 2022, 144, 7457
https://doi.org/10.1021/jacs.2c02188
• Highlighted In Synfacts 2022; 18(07): 0703; DOI: 10.1055/s-0041-1738542
• Synfacts of the Month
• Highlighted on the Organic Chemistry Portal

Modular synthesis of unsymmetrical [1]benzothieno[3,2-b][1]benzothiophene molecular semiconductors for organic transistors
Tayu, M.; Rahmanudin, A.; Perry, G. J. P.; Khan, R. U.; Tate, D. J.; Marcial-Hernandez, R.; Shen, Y.; Dierking, I.; Janpatompong, Y.; Aphichatpanichakul, S.; Zamhuri, A.; Victoria-Yrezabal, I.; Turner, M.L.;* Procter, D. J.*
Chem. Sci. 2022, 13, 421, DOI: 10.1039/D1SC05070B

2021

Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1
Amalina, I.; Bennett, A.; Whalley, H.; Perera, D.; McGrail, J. C.; Tighe, A.; Procter, D. J.; Taylor, S. S.*
R. Soc. open sci. 2021, 8, 210854. 210854
http://doi.org/10.1098/rsos.210854
bioRxiv 2020.07.02.184010; doi: https://doi.org/10.1101/2020.07.02.184010

Modular synthesis of stereodefined benzocyclobutene derivatives via sequential Cu- and Pd-catalysis
Talbot, F. J. T.; Zhang, S.; Satpathi B.; Howell, G. P.; Perry, G. J. P.; Crisenza, G. E. M.; Procter, D. J.*
ACS Catalysis 2021, 11, 14448, doi.org/10.1021/acscatal.1c04496
• Highlighted in Synfacts 2022; 18(02): 0171; DOI: 10.1055/s-0041-1737731

SmI2-catalyzed intermolecular couplings by radical relay
Agasti, S.; Crisenza, G. E. M.; Procter, D. J.*
Trends in Chemistry 2021, 3, 11, 982 (CellPress)
• Invited contribution
• Mechanism of the Month – www.sciencedirect.com/science/article/pii/S2589597421001271?dgcid=author

Enantioselective copper-catalyzed borylative cyclization for the synthesis of quinazolinones
Dherbassy, Q.; Manna, S.; Shi, C.; Prasitwatcharakorn, W.; Crisenza, G. E. M.; Perry, G. J. P.; Procter, D. J.*
Angew. Chem. Int. Ed. 2021, 60, 14355
https://doi.org/10.1002/anie.202103259

Recent Advances in the Chemistry of Ketyl Radicals
Peter, Á.; Agasti, S.; Knowles, O.; Pye, E.; Procter, D. J.*
Chem. Soc. Rev. 2021, 50, 5349

SmI2-Catalyzed Intermolecular Coupling of Cyclopropyl Ketones and Alkynes: A Link between Ketone Conformation and Reactivity
Agasti, S.; Beattie, N. A.; McDouall, J. J. W.; Procter, D. J.*
J. Am. Chem. Soc. 2021, 143, 3655
pubs.acs.org/doi/abs/10.1021/jacs.1c01356

2020

Copper-catalyzed functionalization of enynes
Dherbassy, Q.; Manna, S.; Talbot, F. J. T.; Prasitwatcharakorn, W.;
Perry, G. J. P.; Procter, D. J.*
Chem. Sci. 2020, 11, 11380

Single-scan selective excitation of individual NMR signals in overlapping multiplets
Kiraly, P.*, Kern, N.; Plesniak, M. P.; Nilsson, M.; Procter, D. J.; Morris, G. A.; Adams, R. W.*
Angew. Chem. Int. Ed. 2020, 60, 666

Copper-Catalyzed Borylative Couplings with C–N
electrophiles
Talbot, F. J. T.; Dherbassy, Q.; Manna, S.; Shi, C.;
Zhang, S.; Howell, G. P.; Perry, G. J. P.; Procter, D. J.*
Angew. Chem. Int. Ed. 2020, 59, 20278

Trifluoromethyl sulfoxides: New reagents for metal-free
C–H trifluoromethylthiolation
Wang, D.; Carlton, C. G.; Tayu, M.; McDouall, J. J. W.; Perry, G. J. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2020, 59, 15918

Para-coupling of phenols with C2/C3-substituted benzothiophene S-oxides
He, Z.; Biremond, T.; Perry, G. J. P.; Procter, D. J.
Tetrahedron 2020, 76, 131315
• Invited contribution to the Special Issue, Nuno Maulide: 2020 Tetrahedron Young Investigator Award in Organic Synthesis

Radical C–C bond formation using sulfonium salts and light
Péter, Á.; Perry, G. J. P.; Procter, D. J.
Adv. Synth. Catal. 2020, 362, 2135
• Invited contribution to the Special Issue 'Radical Chemistry and Organic Synthesis', edited by Armido Studer and Dennis Curran
• VIP paper

Enantio- and Diastereoselective Synthesis of Homopropargyl Amines by Copper-Catalyzed Coupling of Imines, 1,3-Enynes, and Diborons
Manna, S.; Dherbassy, Q.; Perry, G. J. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2020, 59, 4879

Sulfoxide-mediated oxidative cross-coupling of phenols
He, Z.; Perry, G. J. P.; Procter, D. J.
Chem. Sci. 2020, 11, 2001
• Highlighted In Synfacts 2020, 16(05), 0529

Metal-Free Photoredox-Catalyzed C–H/C–H Coupling of Arenes Enabled by Interrupted Pummerer Activation
Aukland, M. H.; Šiaučiulis, M.; West, A.; Perry, G. J. P.;
Procter, D. J.
Nature Catalysis 2020, 3, 163
ChemRxiv. 2019, preprint
doi.org/10.26434/chemrxiv.9158564.v1
• Highlighted in Synform – www.thieme.de/en/thieme-chemistry/synform-photoredox-catalysed-formal-C-H-C-H-coupling-of-arenes-157058.htm

Copper-Catalyzed Functionalization of 1,3-Dienes: Hydrofunctionalization, Borofunctionalization and Difunctionalization
Perry, G. J. P.; Jia, T.; Procter, D. J.
ACS Catalysis 2020, 10, 1485

Cascades, Catalysis and Chiral Ligand Control with SmI2; The Rebirth of a Reagent
Péter, Á; Procter, D. J.
Chimia 2020, 74, 018
• Invited contribution to the Special Issue marking the Swiss Chemical Society/Syngenta Symposium: Welcome to the One-electron World

2019

Metal-Free Synthesis of Benzothiophenes by Twofold C–H Functionalization: Direct Access to Materials-Oriented Heteroaromatics
Yan, J.; Pulis, A. P.; Perry, G. J. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2019, 58, 15675.
• Highlighted In Synfacts 2020, 16(02), 0145

Diastereoselective Hydroxyethylation of β-Hydroxyketones: a Reformatsky Cyclization-Lactone Reduction Cascade Mediated by SmI2-H2O
Garduño-Castro, M. H.; Procter, D. J.
Helv. Chim. Acta 2019, 12, e1900227
• Invited contribution to a Special Issue celebrating Prof. Philippe Renaud's 60th birthday

SmI2-Catalyzed Radical Cascade Cyclizations that Construct Quaternary Stereocenters
Huang, H-M.; He, Q.; Procter, D. J.
Synlett 2020, 31, 45
• Invited contribution to the '9th Pacific Symposium on Radical Chemistry' Synlett Cluster
• Selected for the cover of Synlett

Catalytic Cascade Reactions by Radical Relay
Huang, H-M.; Garduño-Castro, M. H.; Morrill, C.; Procter, D. J.
Chem. Soc. Rev., 2019, 48, 4626

Enantioselective and regioselective copper-catalyzed borocyanation of 1-aryl-1,3-butadienes
Jia, T.; Smith, M. J.; Pulis, A. P.; Perry, G. J. P.; Procter, D. J.
ACS Catalysis, 2019, 9, 6744
• Highlighted In Synfacts 2019, 15(09), 1012

Transition metal-free cross-coupling of benzothiophenes and styrenes in a stereoselective synthesis of substituted (E,Z)-1,3-dienes
Šiaučiulis, M.; Ahlsten, N.; Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed., 2019, 58, 8779

The interrupted Pummerer reaction in a sulfoxide-catalyzed oxidative coupling of 2-naphthols
He, Z.; Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed., 2019, 58, 7813
• Highlighted in Synfacts 2019; 15(08): 0926
• Among the top 10% most downloaded papers in the 12 months following online publication #TopDownloadedArticle
• Featured in Organic Process Research & Development (OPRD) 2020 Highlights from the Literature

Pummerer chemistry of benzothiophene S-oxides: Metal-free alkylation and arylation of benzothiophenes
He, Z.; Pulis, A. P.; Perry, G. J. P.; Procter, D. J.
Phosphorus, Sulfur, and Silicon and the Related Elements 2019, 194, 7, 669
• Invited contribution to an ISOCS-28 special issue

Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters
Yeung, K.; Talbot, F. J. T.; Howell, G. P.; Pulis, A. P.; Procter, D. J.
ACS Catalysis, 2019, 9, 1655
• Highlighted in Synfacts 2019; 15(05): 0571

SmI2-catalyzed cyclization cascades by radical relay
Huang, H-M.; McDouall, J. J. W.; Procter, D. J.
Nature Catalysis, 2019, 2, 211
• Highlighted in Nature Reviews Chemistry click here
**For a Freeview link to the paper click here

2018

Transition Metal-Free Synthesis of C3-Arylated Benzofurans from Benzothiophenes and Phenols
Yang, K.; Pulis, A. P.; Perry, G. J. P.; Procter, D. J.
Org. Lett. 2018, 20, 7498

Samarium(II) folding cascades involving hydrogen
atom transfer for the synthesis of complex polycycles
Plesniak, M. P.; Garduño-Castro, M. H.; Lenz, P.; Just-Baringo, X.; Procter, D. J.
Nature Commun. 2018, 9, 4802
• Highlighted by the Editor
• Highlighted in Synfacts 2019; 15(02): 0154

Reductive Cyclisations of Amidines involving Aminal Radicals
Huang, H-M.; Adams, R. W.; Procter, D. J.
Chem. Commun. 2018, 54, 10160
• Chosen by Antonio Echavarren (ICIQ, Spain) to be included in the specially curated collection on “Organic Synthesis”.

Regiodivergent copper catalyzed borocyanation of 1,3-dienes
Tao J.; He, Q.; Ruscoe, R. E.; Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2018 , 57, 11305

Selective electron transfer reduction of urea-type carbonyls
Huang, H-M.; Procter, D. J.
Eur. J. Org. Chem. 2018, accepted article
• Very Important Paper
• Invited contribution to Special Issue “Organic Reaction Mechanisms”
(Guest Editor Professor Peter R. Schreiner).

An interrupted Pummerer/nickel-catalysed cross-coupling sequence
Aukland, M. H.; Talbot, F. J. T.; Fernández-Salas, J. A.; Ball, M.; Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2018, 57, 9785
• ChemCatChem Hot Topic: C-C Coupling

Synthesis of C2 Substituted Benzothiophenes via an Interrupted Pummerer/[3,3]-Sigmatropic/1,2-Migration Cascade of Benzothiophene S-Oxides
He, Z.; Shrives, H. J.; Fernández-Salas, J. A.; Abengózar, A.; Neufeld, J.; Yang,K.; Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2018, 57, 5759
• Highlighted in C2位取代苯并噻吩的高效合成 (in Chinese), 22 May 2018

Radical Anions from Urea-type Carbonyls: Radical Cyclizations and Cyclization Cascades
Huang, H-M.; McDouall, J. J. W.; Procter, D. J.
Angew. Chem. Int. Ed. 2018, 57, 4995
• Highlighted in 脲类羰基自由基引发的环化及串联反应 (in Chinese), 23 April 2018
• Highlighted in 巴比妥酸类化合物的环化反应 (in Chinese), 28 April 2018

Biocatalytic conversion of cyclic ketones bearing α-quaternary stereocenters to lactones in an enantioselective radical approach to medium-sized carbocycles
Morrill, C.; Jensen, C.; Just-Baringo, X.; Grogan, G.; Turner, N. J.; Procter, D. J.
Angew. Chem. Int. Ed. 2018, 57, 3692

Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade
Šiaučiulis, M.; Sapmaz, S.; Pulis, A. P.; Procter, D. J.
Chem. Sci. 2018, 9, 754
• Highlighted in Synfacts 2018; 14(04): 0368;

2017

Radical heterocyclization and heterocyclization cascades triggered by electron transfer to amide-type carbonyls
Huang, H-M.; Procter, D. J.
Angew. Chem. Int. Ed. 2017, 56, 14262
• Highlighted in 酰胺自由基参与的自由基氮杂环化以及氮杂串联环化反应 (in Chinese), 08 Dec 2017

Radical cascade reactions triggered by single electron transfer
Plesniak, M. P.; Huang, H-M; Procter, D. J.
Nature Rev. Chem. 2017, 1, 0077
• Issue cover

Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals
Kern, N.; Plesniak, M. P.; McDouall, J. J. W.; Procter, D. J.
Nature Chem. 2017, 9, 1198
• Featured in Nature, Interactive Periodic Table
• Highlighted in "In Abstract Ed 4"
• Highlighted in Synfacts 2017; 13(11): 1195;
• 二碘化钐介导的自由基不对称串联环化反应 (in Chinese), 10 Sep 2017
• 化学前沿 | Nature Chemistry:二碘• 化钐介导的自由基不对称环化反应及环化串联反应 (in Chinese), 25 Aug 2017

Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
Pulis, A. P.; Yeung, K.; Procter, D. J.
Chem. Sci. 2017, 8, 5240

Selective construction of quaternary stereocentres in radical cyclisation cascades triggered by electron-transfer reduction of amide-type carbonyls
Huang, H. -M.; Bonilla, P.; Procter, D. J.
Org. Biomol. Chem. 2017, 15, 4159
• Invited contribution to themed issue on Polycyclizations in Synthesis and Biosynthesis

Regioselective synthesis of C3 alkylated and arylated benzothiophenes
Shrives, H. J.; Fernández-Salas, J. A.; Hedtke, C.; Pulis, A. P.; Procter, D. J.
Nature Commun. 2017, 8, 14801

Dearomatizing radical cyclizations and cyclization cascades triggered by electron-transfer reduction of amide-type carbonyls
Huang, H. -M.; Procter, D. J.
J. Am. Chem. Soc. 2017, 139, 1661

Reduction of selenoamides to amines using SmI2-H2O
Thurow, S.; Lenardao, E. J.; Just-Baringo, X.; Procter, D. J.
Org. Lett. 2017, 19, 50

Author profile: D. J. Procter
Angew. Chem. Int. Ed. 2017, 56, 5152

2016

SmCp2-mediated cross-couplings of allyl and propargyl ethers with ketoesters and a telescoped approach to cycloheptanols
Plesniak, M. P.; Just-Baringo, X.; Ortu, F.; Mills, D. P.; Procter, D. J.
Chem. Commun. 2016, 52, 13503

Metal-free C–H thioarylation of arenes using sulfoxides : A direct, general diaryl sulfide synthesis
Fernández-Salas, J. A.; Pulis, A. P.; Procter, D. J.
Chem. Commun. 2016, 52, 12364

Selective synthesis of cyclooctanoids by radical cyclization of seven-membered lactones: Neutron diffraction study of the stereoselective deuteration of a chiral organosamarium intermediate
Just-Baringo, X.; Clark, J.; Gutmann, M. J.; Procter, D. J.
Angew. Chem. Int. Ed. 2016, 55, 12499

Enantioselective generation of adjacent stereocenters in a copper-catalyzed three-component coupling of imines, allenes and diboranes
Yeung, K.; Ruscoe, R. E.; Rae, J.; Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2016, 55, 11912
• Hot Paper
• Highlighted in Synfacts 2016; 12(12): 1267
• 铜催化亚胺、联烯和硼试剂的多组分不对称加成反应 (in Chinese), 6 Sep 2016

Radical-radical cyclization cascades of barbiturates triggered by electron-transfer reduction of amide-type carbonyls
Huang, H. -M.; Procter, D. J.
J. Am. Chem. Soc. 2016, 138, 7770
• Highlighted in Radicals in Action: A Festival of Radical Transformations (ACS Select Virtual Issue, March 2017)

Iron-mediated oxidative C-H coupling of arenes and alkenes directed by sulfur: an expedient route to dihydrobenzofurans
Cavanagh, C. W.; M. H. Aukland, Q. Laurent, A. Hennessy, Procter, D. J.
Org. Biomol. Chem. 2016, 14, 5286
• Invited contribution to themed issue on Contemporary Synthetic Chemistry in Drug Discovery

C-H coupling reactions directed by sulfoxides: teaching an old functional group new tricks
Pulis, A. P.; Procter, D. J.
Angew. Chem. Int. Ed. 2016, 55, 9842

Highly selective SmI2-H2O-promoted radical cyclisation of five-membered lactones
Just-Baringo, X.; Morrill, C.; Procter, D. J.
Tetrahedron 2016, 72, 7691
• Invited contribution to Tetrahedron Symposium in Print, "Organic Chemistry - more radical than ever before"

The role of H2O in the electron transfer-activation of substrates using SmI2: insights from DFT
Zhao, X.; Perrin, L.; Procter, D. J.; Maron, L.
Dalton Trans. 2016, 45, 3706

Metal-Free CH-CH-Type Cross-Coupling of Arenes and Alkynes Directed by a Multifunctional Sulfoxide group
Fernández-Salas, J. A.; Eberhart, A. J.; Procter, D. J.
J. Am. Chem. Soc. 2016, 138, 790
• Highlighted in 无金属催化的芳烃和炔的交叉偶联反应 (in Chinese), 28 Jan 2016

Copper-catalyzed borylative cross-coupling of allenes and imines: Selective three-component assembly of branched homoallyl amines
Rae, J.; Yeung, K.; McDouall, J. J. W.; Procter, D. J.
Angew. Chem. Int. Ed. 2016, 55, 1102
• Highlighted in Synfacts 2016; 12(4): 379

Sulfoxide-directed metal-free cross-couplings in the expedient synthesis of benzothiophene-based components of materials
Eberhart, A. J.; Shrives, H.; Zhang, Y.; Carrër, A.; Parry, A. V. S.; Tate, D. J.; Turner, M. L.; Procter, D. J.
Chem. Sci. 2016, 7, 1281

Copper-catalyzed double additions and radical cyclization cascades in the re-engineering of the antibacterial pleuromutilin
Ruscoe, R. E.; Huang, H.; Flitsch, S.; Procter, D. J.
Chem. –Eur. J. 2016, 22, 116

2015

Overcoming synthetic challenges in target synthesis using SmI2: recent advances
Just-Baringo, X.; Yalavac, I.; Procter, D. J.
Organomet. Chem. 2016, 40, 1

Cenp-E inhibitor GSK923295: novel synthetic route and use as a tool to generate aneuploidy
Bennett, A.; Bechi, B.; Tighe, A.; Thompson, S.; Procter, D. J.; Taylor, S. S. Oncotarget. 2015, 6, 20921

MYC Is a Major Determinant of Mitotic Cell Fate
Topham, C.; Tighe, A; Ly, P.; Bennett, A.; Sloss, O.; Nelson, L.; Ridgway, R. A.; Huels, D.; Littler, S.; Schandl, C.; Sun, Y.; Bechi, B.; Procter, D. J.; Sansom, O. J.; Cleveland, D. W.; Taylor, S. S.
Cancer Cell 2015, 28, 129

Iron-mediated C-H Coupling of Arenes and Unactivated Terminal Alkenes Directed by Sulfur
Cavanagh, C. W.; Aukland, M. H.; Hennessy, A.; Procter, D. J.
Chem. Commun. 2015, 51, 9272

Sm(II)-Mediated Electron Transfer to Carboxylic Acid Derivatives: Development of Complexity Generating Cascades
Just-Baringo, X.; Procter, D. J.
Acc. Chem. Res. 2015, 48, 1263
• Invited Account

Sulfoxide-Directed Metal-Free ortho-Propargylation of Aromatics and Heteroaromatics
Eberhart, A. J.; Shrives, H. J.; Álvarez, E.; Carrër, A.; Zhang, Y.; Procter, D. J.
Chem. –Eur. J. 2015, 21, 7428
• Hot paper
• Cover art
• Cover profile